The upregulation of CC chemokine receptor 7 and the increased migration of maturing dendritic cells to macrophage inflammatory protein 3β and secondary lymphoid chemokine is mediated by the p38 stress‐activated protein kinase pathway

• DOI: 10.1046/j.1365-2141.2002.03869.x
• Publication Date: 2003-03-11T06:48:58Z
• Authors: Kirit M. Ardeshna; Arnold R. Pizzey; Simon J. Walker; Stephen Devereux; Asim Khwaja
• Keywords: CCL21; CCL25; CC chemokine receptors; CCL7; CCR2

Summary. Using the p38 stress‐activated protein kinase (p38SAPK) inhibitor, SB203580, increased responsiveness of monocyte‐derived dendritic cells (MoDCs) to secondary lymphoid chemokine (SLC) and macrophage inflammatory 3β (MIP3β), following lipopolysaccharide‐induced MoDC maturation, was shown be mediated by p38SAPK pathway. This due complete abrogation upregulation CC receptor 7, for MIP3β/SLC. Once mature, MoDCs utilized both phosphoinositide‐3 pathways migrate in response SLC or MIP3β. These findings have implications mechanism action inhibitors, currently use clinical trials patients with autoimmune diseases.