Histamine prevents polyamine accumulation in mouse C57.1 mast cell cultures

• DOI: 10.1046/j.1432-1327.2001.01930.x
• Publication Date: 2003-03-11T18:22:38Z
• Authors: Ignacio Fajardo; José L. Urdiales; José C. Paz; Teresa Chavarría; Francisca Sánchez...; Miguel A. Medina
• Keywords: Polyamine; Histamine N-methyltransferase

The effects of histamine on polyamine uptake and metabolism was studied in a mouse mast cell line (C57.1), as model which both biogenic amines are important for maintaining function viability. Results obtained after incubations with exogenous indicated that prevents accumulation by affecting uptake. A plasma membrane transport system polyamines has been also cells. It seems to be Na(+)-dependent high affinity spermine spermidine lower putrescine agmatine. Polyamine reduced cells treated histamine-preloaded However, ornithine decarboxylase activity proliferation were not affected histamine. Incubation enhanced the spermidine/spermine acetyl transferase induction caused N(1)-ethyl-N(11)-[(cyclopropyl)methyl]-4,8-diazaundecane, suggesting acetylation could another mechanism C57.1