Isolation and Characterization of Novel Presenilin Binding Protein

• DOI: 10.1046/j.1471-4159.2000.0750109.x
• Publication Date: 2003-03-12T06:46:09Z
• Authors: Atsushi Kashiwa; Hirotaka Yoshida; Soon Lee; Toni Paladino; Yuanbin Liu; Qi Chen; Richard Dargusch; David Schubert; Hideo Kimura
• Keywords: Cell fractionation

Approximately 50% of familial Alzheimer's disease (AD) cases are linked to the presenilin (PS) gene. This suggests that an altered function mutated PSs accounts for a fundamental process leading AD. Here we identify new PS binding protein, PBP, which is highly expressed in cerebral cortex and hippocampus. immunohistochemical studies cell fractionation analysis show PBP redistributes from cytoplasm membranes presence PS. In addition, deficient soluble fraction sporadic AD brains.