The Human Brain Has Distinct Regional Expression Patterns of Estrogen Receptor α mRNA Isoforms Derived from Alternative Promoters

• DOI: 10.1046/j.1471-4159.2000.0751390.x
• Publication Date: 2003-03-12T06:48:15Z
• Authors: Marie K. Österlund; Kaj Grandien; Eva Keller; Yasmin L. Hurd
• Keywords: Estrogen receptor alpha; Forebrain; Estrogen receptor beta

Abstract: The human estrogen receptor (ER) α gene is transcribed from multiple promoters, generating mRNA isoforms with unique 5′ ends in the untranslated region. In present study, alternative promoters were shown to regulate ERα expression different neuronal populations of brain. By using situ hybridization histochemistry, A and B but not C promoter, found be active forebrain. isoform promoter was expressed low levels most brain areas where present. contrast, more restricted, localized predominantly high‐expressing regions. gross anatomical distribution analyzed RT‐PCR generally supported results obtained by hybridization. Estrogen known modulate many functions, such as neuroendocrine events associated reproduction, mood, cognition, likely mediated populations. Thus, current findings distinct suggest that usage a possible mechanism achieve differentiated regulation expression, dependent on cell phenotype consequently functions specific neuron.