Interaction between mitochondria and oxidative stress in neuronal injury

• DOI: 10.1046/j.1471-4159.85.s2.3_1.x
• Publication Date: 2003-05-08T13:18:21Z
• Authors: I. J. Reynolds; A. J. Filiano; L. M. Malaiyandi; G. L. Rintoul; T. V. Votyakova
• Keywords: Excitotoxicity

Mitochondria may be both the source and target of oxidative stress in neurodegenerative disease. In models excitotoxicity, neuronal injury is triggered by influx calcium into neurons then mitochondria. Our studies suggest that an important consequence this movement generation ROS Studies with isolated mitochondria enhance mitochondria, especially when complex I impaired. However, these are complicated a lack specificity detection methods like Amplex Red. One feature their within neurons. We used fluorescent proteins targeted to follow trafficking Neurotoxins glutamate, zinc peroxide, which mechanism action, affect mitochondrial movement, morphology or both. speculate restricting delivery targets could impair viability.