Correlation between functional assessment staging and the ‘Basic Age’ by the Binet scale supports the retrogenesis model of Alzheimer's disease: a preliminary study

• DOI: 10.1046/j.1479-8301.2003.00015.x
• Publication Date: 2003-09-11T16:30:59Z
• Authors: Masumi SHIMADA; Jabeen HAYAT; Kenichi MEGURO; Thet OO; Syed JAFRI; Atsushi YAMADORI; Emile H. FRANSSEN; Barry REISBERG
• Keywords: Concordance; Stanford–Binet Intelligence Scales

Abstract Background: In the progression of their disease, Alzheimer's disease (AD) patients have been observed to demonstrate various clinical features reminiscent children. Based on behavioral, neurological and neuropathological findings, Reisberg et al . noted relationships between development dementia proposed ‘retrogenesis’ model. Methods: The functional assessment staging procedure (FAST) was used for ability, Tanaka–Binet intelligence scale (TB scale) assess intellectual ability in 24 with moderate severe AD. Results: Overall, there a significant Spearman's correlation FAST stage basic age (BA) value ( r = −0.85, P < 0.01). BA by TB significantly different stages 5 6 7. mean (standard error [SE]) values were 4.2 (0.9) 2.3 (0.7), respectively, latter being lower than former F 10.2, 0.01 one‐way anova ). could not 7 because floor effects. Conclusion: Although further investigation using larger samples would be needed, findings support general concordance decline AD converse developmental acquisition same capacities, as hypothesized retrogenesis