Endoscopic Submucosal Dissection in Europe: Results of 1000 Neoplastic Lesions From the German Endoscopic Submucosal Dissection Registry

• DOI: 10.1053/j.gastro.2021.06.049
• Publication Date: 2021-06-26T07:03:36Z
• Authors: Carola Fleischmann; Andreas Probst; Alanna Ebigbo; Siegbert Faiss; Brigitte Schumacher; H.-P. Allgaier; F.L. Dumoulin; Ingo Steinbrueck; Michael Anzinger; Joerg Marienhagen; Anna Muzalyova; Helmut Messmann
• Keywords: Endoscopic submucosal dissection; Endoscopic mucosal resection

Endoscopic submucosal dissection (ESD) enables the curative resection of early malignant lesions and is associated with reduced recurrence risk. Due to lack comprehensive ESD data in West, German registry was set up evaluate relevant outcomes ESD.The a prospective uncontrolled multicenter study. During 35-month period, 20 centers included 1000 ESDs neoplastic lesions. The results were evaluated terms en bloc, R0, rates, rate after 3-month 12-month follow-up. Additionally, participating grouped into low-volume (≤20 ESDs/y), middle-volume (20-50/y), high-volume (>50/y). A multivariate analysis investigating risk factors for noncurative performed.Overall, rates 92.4% (95% confidence interval [CI], 0.90-0.94), 78.8% CI, 0.76-0.81), 72.3% 0.69-0.75) achieved, respectively. overall complication 8.3% 0.067-0.102), whereas 12 months 2.1%. High-volume had significantly higher lower than middle- or centers. lesion size, hybrid ESD, age, stage T1b carcinoma, treatment outside identified as ESD.In Germany, achieves excellent bloc but only modest rates. requires high level expertise, vary depending on center's yearly case volume.