Regioselective Synthesis of 1,4-Disubstituted 1,2,3-Triazoles: Advances in Click Chemistry and Multicomponent Reaction Engineering

• DOI: 10.1055/a-2564-4826
• Publication Date: 2025-03-22T00:58:52Z
• Authors: Priyanka Gogoi; Kalyanjyoti Deori; Diganta Sarma

Regioselective synthesis of 1,2,3-triazoles has emerged as a cornerstone of modern synthetic chemistry, offering immense potential in pharmaceuticals, materials science, and functional applications. This account focuses on advancing click reaction, with majority of the innovations stemming from our group’s contributions. Highlights include the development of novel catalytic systems, both homogeneous and heterogeneous and the exploration of copper-free and photocatalytic methodologies. This account bridges traditional and modern approaches, offering mechanistic insights and engineering strategies to improve regioselectivity and efficiency. This work envisions a transformative feature for azide-alkyne cycloaddition, advancing from copper-based or copper-free catalysis to light-driven innovations.