Ticlopidine Selectively Inhibits Human Platelet Responses to Adenosine Diphosphate

• DOI: 10.1055/s-0038-1646487
• Publication Date: 2018-07-26T22:31:06Z
• Authors: Marco Cattaneo; Benjaporn Akkawat; Anna Lecchi; Claudio Cimminiello; Anna M Capitanio; Pier Mannuccio Ma...
• Keywords: Ticlopidine; Apyrase; Adenosine diphosphate; Clot retraction

Summary Platelet aggregation and fibrinogen binding were studied in 15 individuals before 7 days after the oral administration of ticlopidine (250 mg b.i.d.). Ticlopidine significantly inhibited platelet induced by adenosine diphosphate (ADP), endoperoxide analogue U46619, collagen or low concentrations thrombin, but did not inhibit epinephrine high thrombin. 125I-fibrinogen ADP, U46619 thrombin (1 U/ml). The ADP scavengers apyrase CP/CPK, added vitro to suspensions obtained ticlopidine, caused same pattern 125I-fibrihogen inhibition as ticlopidine. further presence scavengers. After administration, increased rate anti-GPIIb/IIIa monoclonal antibody 7E3 platelets. clot retraction reptilase plus that epinephrine, prevented inhibitory effect on PGE1-induced increase cyclic AMP. number high- low-affinity sites for 3H-ADP formalin-fixed platelets their K d modified These findings indicate selectively inhibits responses ADP.