Fetal/Neonatal Pericardial Effusion in Down's Syndrome: Case Report and Review of Literature

• DOI: 10.1055/s-0038-1675337
• Publication Date: 2018-10-30T00:45:48Z
• Authors: Pramod Pharande; Kiran Balegar Vir...; Bhavesh Mehta; Nadia Badawi
• Keywords: 03 medical and health sciences; 0302 clinical medicine; transient myeloproliferative disorder; steroid; RG1-991; hypothyroidism; Gynecology and obstetrics; pericardial effusion; down's syndrome; 3. Good health

We report a preterm (35 4/7 weeks) male neonate with Down's syndrome (DS) diagnosed isolated pericardial effusion (PE) at 20 weeks of gestation. He was born by precipitous delivery, needed no resuscitation and presented within first 24 hours life respiratory distress, anemia due to feto-maternal bleed, hypotension, hepatomegaly, coagulopathy. Postnatal echocardiography confirmed 5 mm rim PE without tamponade, normal cardiac structure, function. stabilized ventilation, packed red cell, fresh frozen plasma, inotropes (dopamine, dobutamine, adrenaline), steroid (hydrocortisone). Subsequent evaluation hypothyroidism, transient myeloproliferative disorder (TMD), hepatic failure fibrosis/cirrhosis portal hypertension, sensitive hypotension on two occasions possibly adrenal insufficiency. completely resolved over 2 weeks. In view progressively worsening liver ascites the family opted for palliation. Literature review has been discussed regarding perinatal onset in DS.