First Comparative Study of the Effectiveness of the Use of Tranexamic Acid against ε-Aminocapróic Acid via the Oral Route for the Reduction of Postoperative Bleeding in TKA: A Clinical Trial
Male
Administration, Oral
Middle Aged
Postoperative Hemorrhage
Antifibrinolytic Agents
3. Good health
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Tranexamic Acid
Aminocaproic Acid
Humans
Blood Transfusion
Female
Prospective Studies
Arthroplasty, Replacement, Knee
Aged
DOI:
10.1055/s-0039-1696722
Publication Date:
2019-09-06T23:18:26Z
AUTHORS (11)
ABSTRACT
Total primary knee replacement results in significant postoperative bleeding. There are reports that 20 to 50% of the patients require a blood transfusion, which has been related many complications, resulting search for strategies reduce The use oral antifibrinolytics is becoming low cost and safe way achieving this goal. hypothesis study was aminocaproic acid could provide similar tranexamic (TXA). purpose compare effects as hemostatic agent versus TXA administered multiple doses pre postsurgery undergoing total replacement. We enrolled 92 were randomly divided into two groups: received three (2,000 mg per dose) or (1,300 dose). drugs according following schedule: 2 hours before surgery 6 12 after surgery. variables analyzed effectiveness agents loss; hidden external transfusion rate; intraoperative decreases hemoglobin hematocrit values; surgical drainage output; visual analogue scale; complications. no differences between any group receiving (p > 0.05), with exception who TXA, presented more adverse events = 0.04). Our showed its counterpart regarding evaluated parameters. Although an average 140 mL less loss than ε-ACA group, difference did not appear be clinically important, rate very low, there between-group
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