Photoinduced Synthesis of 2-Trifluoromethylated Indoles through Oxidative Trifluoromethylation Using Langlois’ Reagent in the Absence of External Photocatalyst

• DOI: 10.1055/s-0040-1720093
• Publication Date: 2023-10-06T05:44:45Z
• Authors: Deepak K. Sharma; Samarpita Das; Harish K. Indurthi; Amita Kumari
• Keywords: Trifluoromethylation

Abstract A photoinduced approach for regioselective C-2 trifluoromethylation of indoles was achieved with CF3SO2Na under UV light irradiation (360–365 nm) at ambient conditions without any external photo activator. The key steps involve the in situ conversion reagent to CF3 • radical oxygen or air and irradiation. This proficient method has advantages mild reaction conditions, fair substrate tolerability, gram scalability.