Palladium-catalyzed 3-Thiomethyltriazine-boronic Acid Cross Coupling: Easy Access to 3-Substituted-1,2,4-triazines

• DOI: 10.1055/s-2002-20462
• Publication Date: 2002-07-26T07:47:25Z
• Authors: France-Aimée Alph...; Franck Suzenet; Anne Keromnes; Bruno Lebret; Gérald Guillaumet
• Keywords: Boronic acid; Triazine; Coupling reaction

The palladium-catalyzed coupling reaction of 3-thiomethyl-1,2,4-triazine 1 with different organoboron compounds in the presence copper(I) 3-methylsalicylate proceeds to afford corresponding 3-substituted-1,2,4-triazines good yield. This approach leads very easily a large range C-5 and C-6 unsubstituted as-triazines.