Loudness Dependence of Primary Auditory-Cortex-Evoked Activity as Predictor of Therapeutic Outcome to Prophylactic Lithium Treatment in Affective Disorders - A Retrospective Study

• DOI: 10.1055/s-2004-815524
• Publication Date: 2004-03-29T13:12:32Z
• Authors: Georg Juckel; Paraskevi Mavrogi...; S. Bredemeier; Jürgen Gallinat; Thomas Frodl; Carl O. Schulz; H.‐J. Möller; Ulrich Hegerl
• Keywords: Adult; Auditory Cortex; Male; Mood Disorders; Electroencephalography; Lithium; Middle Aged; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Antimanic Agents; Predictive Value of Tests; Reference Values; Evoked Potentials, Auditory; Humans; Female; Retrospective Studies

Introduction: Lithium has been found to be very effective in prophylactic treatment of affective disorders. However, approximately one-third patients do not respond this treatment, which does become apparent until after a year or more treatment. Therefore, predictors are needed avoid long and unsuccessful therapy with risk severe side effects. Since lithium acts as serotonin agonist predictor being able identify low serotonergic activity, who may responders lithium, is promising. To determine whether the loudness dependence (LDAEP) primary, but secondary, auditory-cortex-evoked inversely related central neurotransmission, could such predictor, non-responders were compared. Methods: Thirty uni- bipolar disorders, have taken medication continuously for at least 3 years, included study. Patients classified if they had no hospitalization within past years. Dipole source analysis allowing us separate evoked activity primary secondary auditory cortex was used. Results: The LDAEP significantly stronger than non-responders, implicating function these patients. Discussion: This finding, line previous studies, suggests that clinically relevant