Pharmacological Studies on Leaves ofWithania somnifera

• DOI: 10.1055/s-2007-969072
• Publication Date: 2007-03-07T13:02:54Z
• Authors: S. Sudhir; R. Budhiraja; G. Miglani; B. Arora; L. Gupta; K. Garg
• Keywords: 0303 health sciences; 03 medical and health sciences; Plants, Medicinal; Time Factors; Carbon Tetrachloride Poisoning; Plant Extracts; Anti-Inflammatory Agents; Animals; India; Chemical and Drug Induced Liver Injury; Rats; 3. Good health

Anti-inflammatory activity and protective effect against CCl 4 -induced hepatotoxicity of alcoholic extract of leaves of WITHANIA SOMNIFERA have been assessed. The leaves were found to possess marked effects in subacute inflammation and hepatotoxicity. A comparison of the anti-inflammatory properties revealed the extract at 1 g/kg dose to be as active as 50 mg/kg of phenylbutazone and 10 mg/kg of hydrocortisone. The protective effect of the extract at 1 g/kg dose against CCl 4 -induced hepatotoxicity was comparable to 10 mg/kg of hydrocortisone.