Antifertility Effects of Chronically Administered Malvaviscus conzattii Flower Extract on Male Albino Mice

• DOI: 10.1055/s-2007-971714
• Publication Date: 2007-04-02T09:10:03Z
• Authors: B. Joshi; Santosh Kumar; O. Verma; S. Chatterjee; D. Jacob
• Keywords: Male; 0301 basic medicine; Mice; 03 medical and health sciences; Plant Extracts; Contraceptive Agents, Male; Animals

The antifertility effects of alcoholic extract Malvaviscus conzattii flowers were observed on male albino mice after oral administration 30 and 50 doses (one dose = mg/day/mouse). genital degenerative changes found to be more pronounced when the results doses. drug resulted in mass atrophy spermatogenic elements testicular stages left with only 1-2 cell layers. Epididymal epithelium was regressed lumina either devoid spermatozoa or contained its debris. flower treatment produced a significant decrease absolute weights testes, epididymes, vas deferens seminal vesicles. Administration reduction levels protein (P < 0.001; P 0.001 0.001) sialic acid 0.005; 0.005 epididymes vesicle respectively. Glyceryl phosphoryl choline also reduced significantly at In contrast, contents cholesterol glycogen elevated Alkaline phosphatase activity vesicles remained within normal range. Fructose doses, then attained normaly Reduced androgen production reflected low conclusion, M. caused an effective impairment spermatogenesis thus inducing state.