Improved Fenton Therapy Using Cancer Cell Hydrogen Peroxide

• DOI: 10.1071/ch18281
• Publication Date: 2018-09-19T00:22:10Z
• Authors: Hadi Ranji-Burach...; Qiang Fu; Paul A. Gurr; Dave E. Dunstan; Greg G. Qiao
• Keywords: HeLa; Viability assay

Fenton cancer therapy as a new methodology for the treatment of tumour cells is largely restricted owing to low stability, high aggregation, and poor selectivity reported nanoparticles. In this study, an improved approach selective destruction reported. Metal–organic framework (MOF) nanoparticles were synthesized reduced via hydrothermal method, then PEGylated through surface-initiated atom transfer radical polymerization (SI-ATRP) reaction produce MOF (P@rMOF). The ratio PEG was used optimize size aggregation nanoparticles, with 2P@rMOF (2 : 1 mass ratio) having smallest hydrodynamic diameter. further conjugated folic acid cell targeting. vitro uptake experiments demonstrated that internalization 2P@rMOF-FA into (HeLa) almost 3-fold normal (NIH-3T3). presence 2P@rMOF-FA, HeLa viability decreased dramatically 22 %, whereas NIH-3T3 remained higher than 80 % after 24 h incubation. index 4.48, which significantly those in literature similar strategies. This work thus demonstrates most stable nanoparticle system using cell’s own H2O2.