Baicalin improves IVM of pig oocytes and subsequent preimplantation embryo development by inhibiting apoptosis

• DOI: 10.1071/rd18333
• Publication Date: 2019-03-01T02:08:36Z
• Authors: Qing Guo; Mei-Fu Xuan; Zhao-Bo Luo; Jun-Xia Wang; Song-Shan Jin; Xi-Jun Yin; Jin-Dan Kang
• Keywords: Baicalin

Baicalin, a monomer of flavonoids extracted from dried roots Scutellaria baicalensis, is used to treat female infertility. However, the effect baicalin on oocyte maturation unknown. In this study we investigated effects IVM pig oocytes and subsequent embryo development following parthenogenetic activation (PA). We found that 0.1µgmL-1 significantly (P<0.05) increased rate compared with non-treatment (control) group by reducing levels reactive oxygen species (ROS). addition, mRNA expression genes related nuclear cumulus cell expansion, mitochondrial membrane potential ATP content was higher in baicalin-treated than control oocytes. To determine whether treatment during improves PA embryos, measured cleavage blastocyst formation rates, as well number cells per blastocyst. All these parameters were group. conclusion, demonstrates invitro inhibiting production ROS apoptosis