Estrogen receptor β inhibits 17β-estradiol-stimulated proliferation of the breast cancer cell line T47D

• DOI: 10.1073/pnas.0308319100
• Publication Date: 2004-02-10T18:32:51Z
• Authors: Anders Ström; Johan Hartman; James S. Foster; Silke Kietz; Jay Wimalasena; Jan-Åke Gustafsson
• Keywords: CDK inhibitor; CDC25A; Cyclin E

Estrogen receptor (ER) β counteracts the activity of ERα in many systems. In agreement with this, we show this study that induced expression ERβ breast cancer cell line T47D reduces 17β-estradiol-stimulated proliferation when mRNA equals ERα. Induction growth exponentially proliferating cells a concomitant decrease components cycle associated proliferation, namely cyclin E, Cdc25A (a key regulator Cdk2), p45 Skp2 p27 Kip1 proteolysis), and an increase Cdk inhibitor . We also observed reduced Cdk2 activity. These findings suggest possible role for imply ERβ-specific ligands may reduce ER-positive through actions on G 1 phase cell-cycle machinery.