Hormonal activity of AIMP1/p43 for glucose homeostasis

• DOI: 10.1073/pnas.0602045103
• Publication Date: 2006-09-26T01:03:54Z
• Authors: Sang Gyu Park; Young Sun Kang; Jin Young Kim; Chang Seok Lee; Young Gyu Ko; Woo Je Lee; Ki-Up Lee; Young Il Yeom; Sunghoon Kim
• Keywords: Male; 0301 basic medicine; Gene Expression Profiling; Lipolysis; Glycogenolysis; Glucagon; Hypoglycemia; 3. Good health; Mice, Inbred C57BL; Mice; Protein Transport; 03 medical and health sciences; Glucose; Phenotype; Glucagon-Secreting Cells; 3T3-L1 Cells; Animals; Cytokines; Homeostasis

AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic α cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.