Memory enhancement in healthy older adults using a brain plasticity-based training program: A randomized, controlled study

• DOI: 10.1073/pnas.0605194103
• Publication Date: 2006-08-04T00:48:29Z
• Authors: Henry W. Mahncke; Bonnie B. Connor; Jed Appelman; Omar N. Ahsanuddin; Joseph L. Hardy; Richard A. Wood; Nicholas M. Joyce; Tania Boniske; Sharona M. Atkins; Michael M. Merzenich
• Keywords: Cognitive Training

Normal aging is associated with progressive functional losses in perception, cognition, and memory. Although the root causes of age-related cognitive decline are incompletely understood, psychophysical neuropsychological evidence suggests that a significant contribution stems from poorer signal-to-noise conditions down-regulated neuromodulatory system function older brains. Because brain retains lifelong capacity for plasticity adaptive reorganization, dimensions negative reorganization should be at least partially reversible through use an appropriately designed training program. We report here results such program targeting decline. Data randomized, controlled trial using standardized measures as outcomes presented. Significant improvements assessments directly related to tasks generalization nonrelated memory (effect size 0.25) were documented group Memory enhancement appeared sustained after 3-month no-contact follow-up period. Matched active control groups showed no change or follow-up. This study demonstrates intensive, plasticity-engaging can result normal mature adults.