IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth

• DOI: 10.1073/pnas.0702031104
• Publication Date: 2007-06-14T04:03:28Z
• Authors: Chatarina Lofqvist; Jing Chen; Kip M. Connor; Alexandra C. H. S...; Christopher M. Ad...; Nan Liu; John E. Pintar; Thomas Ludwig; Ann Hellstrom; Lois E. H. Smith
• Keywords: IGFBP3

Vessel loss precipitates many diseases. In particular, vessel resulting in hypoxia induces retinal neovascularization diabetic retinopathy and of prematurity (ROP), major causes blindness. Here we define insulin-like growth factor binding protein-3 (IGFBP3) as a new modulator vascular survival regrowth oxygen-induced retinopathy. IGFBP3-deficient mice, there was dose-dependent increase loss. Subsequent to loss, Igfbp3(-/-) mice had 31% decrease versus controls after returning room air. No difference serum 1 (IGF1) levels observed among groups. Wild-type treated with exogenous IGFBP3 significant regrowth. This correlated 30% endothelial progenitor cells the retina at postnatal day 15, indicating that could be serving cell chemoattractant. prospective clinical study, measured (and IGF1) plasma weekly examined retinas all premature infants born gestational ages <32 weeks high risk for ROP. The mean level 30-35 postmenstrual age (PMA) proliferative ROP (ROP stages 3>, n = 13) 802 microg/liter, no stage 0, 38) 974 microg/liter (P < 0.03). These results suggest IGFBP3, acting independently IGF1, helps prevent promote destruction vivo manner, less neovascularization.