Correspondence of the brain's functional architecture during activation and rest

• DOI: 10.1073/pnas.0905267106
• Publication Date: 2009-07-22T01:07:45Z
• Authors: Stephen M. Smith; Peter T. Fox; Karla L. Miller; David C. Glahn; P. Mickle Fox; Clare E. Mackay; Nicola Filippini; Kate E. Watkins; Roberto Toro; Angela R. Laird; Christian F. Beck...
• Keywords: Rest (music); Neural substrate; Brain mapping; Nerve net; Human brain

Neural connections, providing the substrate for functional networks, exist whether or not they are functionally active at any given moment. However, it is known to what extent brain regions continuously interacting when "at rest." In this work, we identify major explicit activation networks by carrying out an image-based network analysis of thousands separate maps derived from BrainMap database imaging studies, involving nearly 30,000 human subjects. Independently, extract covarying in resting brain, as imaged with magnetic resonance 36 subjects rest. The sets and their decompositions into subnetworks, show close correspondence between independent analyses dynamics. We conclude that full repertoire utilized action dynamically "active" even "rest."