Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts

• DOI: 10.1073/pnas.0911346107
• Publication Date: 2010-04-06T00:35:31Z
• Authors: J. H. Duncan Bassett; Alan Boyde; Peter G. T. Howell; Richard H. Bassett; Thomas M. Galliford; Marta Archanco; Holly Evans; Michelle A. Lawson; Peter Croucher; Donald L. St. Ger...; Valerie Anne Galton; Graham R. Williams
• Keywords: Iodothyronine deiodinase; DIO2

Hypothyroidism and thyrotoxicosis are each associated with an increased risk of fracture. Although thyroxine (T4) is the predominant circulating thyroid hormone, target cell responses determined by local intracellular availability active hormone 3,5,3′-L-triiodothyronine (T3), which generated from T4 type 2 deiodinase enzyme (D2). To investigate role locally produced T3 in bone, we characterized mice deficient D2 (D2KO) serum level normal. Bones adult D2KO have reduced toughness brittle, displaying susceptibility to This phenotype a 50% reduction bone formation generalized increase skeletal mineralization resulting deficiency osteoblasts. These data reveal essential for osteoblasts optimization strength mineralization.