Intestinal alkaline phosphatase prevents metabolic syndrome in mice

• DOI: 10.1073/pnas.1220180110
• Publication Date: 2013-04-09T01:18:31Z
• Authors: Kanakaraju Kaliannan; Sulaiman R. Hamarneh; Konstantinos P. E...; Sayeda Nasrin Alam; Omeed Moaven; Palak Patel; Nondita S. Malo; Madhury Ray; Seyed M. Abtahi; Nur Muhammad; Atri Raychowdhury; Abeba Teshager; Mussa M. Rafat Mo...; Angela K. Moss; Rizwan Ahmed; Shahrad Hakimian; Sonoko Narisawa; José Luis Millán; Elizabeth Hohmann; H. Shaw Warren; Atul K. Bhan; Madhu S. Malo; Richard A. Hodin
• Keywords: Dyslipidemia

Metabolic syndrome comprises a cluster of related disorders that includes obesity, glucose intolerance, insulin resistance, dyslipidemia, and fatty liver. Recently, gut-derived chronic endotoxemia has been identified as primary mediator for triggering the low-grade inflammation responsible development metabolic syndrome. In present study we examined role small intestinal brush-border enzyme, alkaline phosphatase (IAP), in preventing high-fat-diet-induced mice. We found both endogenous orally supplemented IAP inhibits absorption endotoxin (lipopolysaccharides) occurs with dietary fat, oral supplementation prevents well reverses Furthermore, improves lipid profile mice fed standard, low-fat chow diet. These results point to potentially unique therapy against at-risk humans.