Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis

• DOI: 10.1073/pnas.1300873110
• Publication Date: 2013-06-20T04:35:41Z
• Authors: Shuet Theng Lee; Min Feng; Yong Wei; Zhimei Li; Yuanyuan Qiao; Peiyong Guan; Xia Jiang; Chew Hooi Wong; Kelly Huynh; Jinhua Wang; Juntao Li; K. Murthy Karuturi; Ern Yu Tan; Dave S. B. Hoon; Yibin Kang; Qiang Yu
• Keywords: Triple-negative breast cancer

Efforts to improve the clinical outcome of highly aggressive triple-negative breast cancer (TNBC) have been hindered by lack effective targeted therapies. Thus, it is important identify specific gene targets/pathways driving invasive phenotype develop more therapeutics. Here we show that ubiquitin-associated and SH3 domain-containing B (UBASH3B), a protein tyrosine phosphatase, overexpressed in TNBC, where supports malignant growth, invasion, metastasis largely through modulating epidermal growth factor receptor (EGFR). We also UBASH3B functional target anti-invasive microRNA200a (miR200a) down-regulated TNBC. Importantly, oncogenic potential dependent on its phosphatase activity, which targets CBL ubiquitin ligase for dephosphorylation inactivation, leading EGFR up-regulation. may function as crucial node bridging multiple invasion-promoting pathways, thereby providing therapeutic