A naturally occuring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms

• DOI: 10.1073/pnas.1316235110
• Publication Date: 2013-10-15T00:21:48Z
• Authors: Morgane Thomas-Ch...; Lisa C. Watson; Samantha B. Cooper; Miles A. Pufall; Jennifer S. Liu; Katja Borzym; Martin Vingron; Keith R. Yamamoto; Sebastiaan H. Mei...
• Keywords: Sequence (biology)

Significance For proteins to be able have context-specific activities, they can adopt conformations that enhance or restrict their activity. transcriptional regulatory factors, such a signal is provided by the sequence of DNA response element which it binds. Here we show how one signal, an alternative splicing event, rewires protein respond differently second binds, changing functional interplay between domains. Together, our findings argue bidirectional allosteric signaling DNA:protein interface and other domains fine tunes activity factors toward individual target genes.