Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals

• DOI: 10.1073/pnas.1321195111
• Publication Date: 2014-01-22T04:02:30Z
• Authors: Yanchang Wei; Cai-Rong Yang; Yan-Ping Wei; Zhen-Ao Zhao; Yi Hou; Heide Schatten; Qing-Yuan Sun
• Keywords: Prediabetes; TCF7L2; Pancreatic Islets

The global prevalence of prediabetes and type 2 diabetes (T2D) is increasing, it contributing to the susceptibility its related epidemic in offspring. Although impacts paternal impaired fasting blood glucose intolerance on metabolism offspring have been well established, exact molecular mechanistic basis that mediates these remains largely unclear. Here we show increases through gametic epigenetic alterations. In our findings, led insulin resistance Relative controls, prediabetic fathers exhibited altered gene expression patterns pancreatic islets, with down-regulation several genes involved signaling pathways. Epigenomic profiling islets revealed numerous changes cytosine methylation depending prediabetes, including reproducible over genes. Paternal overall methylome sperm, a large portion differentially methylated overlapping Our study uniquely can be inherited transgenerationally mammalian germ line by an mechanism.