Differential uptake of nanoparticles by endothelial cells through polyelectrolytes with affinity for caveolae

• DOI: 10.1073/pnas.1322356111
• Publication Date: 2014-02-11T06:09:20Z
• Authors: Julia Voigt; Jon Christensen; V. Prasad Shastri
• Keywords: Polymers; Blotting, Western; Static Electricity; Endothelial Cells; Fluorescent Antibody Technique; 02 engineering and technology; Chemical Engineering; Caveolae; Flow Cytometry; Real-Time Polymerase Chain Reaction; Cell Line; Electrolytes; Mice; Drug Delivery Systems; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Neoplasms; Animals; Humans; Nanoparticles; Sulfonic Acids; 0210 nano-technology

Significance Nanoparticles (NPs) can serve as containers for the targeting of therapeutics to tumors. Tumors comprise many cell types including endothelial cells that form blood vessels. Developing new strategies target information preferentially have major implications in development targeted therapeutics. We discovered charged polymers containing aromatic sulfonate pronounced affinity caveolae, which are highly expressed by cells. By engineering surface lipid NPs bear sulfonate-containing polymers, taken up been demonstrated.