Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis

• DOI: 10.1073/pnas.1324235111
• Publication Date: 2014-08-20T03:39:11Z
• Authors: Sunday S. Oladipupo; Craig Smith; Andrea Santeford; Changwon Park; Abdoulaye Sene; Luke A. Wiley; Patrick Osei-Owusu; Joann Hsu; Nicole Zapata; Fang Liu; Rei Nakamura; Kory J. Lavine; Kendall J. Blumer; Kyunghee Choi; Rajendra S. Apte; David M. Ornitz
• Keywords: Homeostasis

Significance FGF receptor (FGFR) signaling is thought to be essential for vascular development, homeostasis, and pathological angiogenesis. However, the in vivo requirements cellular targets of vasculature are not known. Here, we show that endothelial FGFR1 FGFR2 required homeostasis or physiological functions likely embryonic development. neovascularization after skin eye injury following retinal ischemia. These findings reveal a key requirement cell-autonomous FGFR tissue repair validate cell as target diseases associated with aberrant proliferation such age-related macular degeneration, diabetic retinopathy, wound healing.