RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation

• DOI: 10.1073/pnas.1407097111
• Publication Date: 2014-10-14T04:00:15Z
• Authors: Woosook Kim; David A. Barron; Rebeca San Martin; Keith S. Chan; Linda L. Tran; Feng Yang; Steven J. Ressler; David R. Rowley
• Keywords: Myofibroblast; RUNX1

Significance Recruitment, proliferation, and differentiation of myofibroblasts are common in many disease states. Mechanisms that regulate proliferation poorly understood, although TGF-β is a key inducer differentiation. Here, we report, for the first time to our knowledge, runt-related transcription factor 1 (RUNX1) regulates mesenchymal stem cell (MSC) biology progenitor commitment myofibroblasts. In this work, describe identification, tissue-resident MSCs from adult normal human prostate gland role these as myofibroblast precursors. We also pinpoint RUNX1 regulating both marrow-derived MSCs. Perturbation activity may provide insights developing antifibrotic anticancer therapies via targeting reactive stroma microenvironment.