Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma

• DOI: 10.1073/pnas.1501735112
• Publication Date: 2015-03-03T03:13:24Z
• Authors: Kalpana Kannan; Cristian Coarfa; Pei-Wen Chao; Liming Luo; Yan Wang; Amy E. Brinegar; Shannon M. Hawkins; Aleksandar Milosa...; Martin M. Matzuk; Laising Yen
• Keywords: AKT2

Significance High-grade serous ovarian cancer (HGSC) is the most common subtype of and typically detected only at advanced stages due to lack effective early screening tools. Fusion genes are among cancer-specific signatures known and, when highly recurrent, they have potential serve as Here we identified BCAM-AKT2 a fusion gene present in 7% HGSC tumors, significant frequency this heterogeneous disease. This results an aberrant kinase whose constant activity contributes formation. Thus, could be important for understanding identifying clinically relevant subtypes HGSC, novel therapeutic target developing small-molecule drugs.