Hydrogel-laden paper scaffold system for origami-based tissue engineering

• DOI: 10.1073/pnas.1504745112
• Publication Date: 2015-12-01T04:15:18Z
• Authors: Su-Hwan Kim; Hak Rae Lee; Seung Jung Yu; Min-Eui Han; Doh Young Lee; Soo Yeon Kim; Hee-Jin Ahn; Mi-Jung Han; Tae-Ik Lee; Taek-Soo Kim; Seong Keun Kwon; Sung Gap Im; Nathaniel S. Hwang
• Keywords: Paper; Mice, Inbred BALB C; 0303 health sciences; Compressive Strength; Alginates; Hexuronic Acids; Maleates; Mice, Nude; Neovascularization, Physiologic; Spectrometry, X-Ray Emission; Hydrogel, Polyethylene Glycol Dimethacrylate; Molecular Weight; 03 medical and health sciences; Cartilage; Chondrocytes; Glucuronic Acid; Microscopy, Electron, Scanning; Animals; Humans; Polystyrenes; Rabbits; HeLa Cells

Significance This work describes an intriguing strategy for the formation of hydrogel-laden multiform structures utilizing paper sheets and suggests a route trachea tissue engineering. It combines concepts extracted from origami, functional thin polymer coating, hydrogel layering on top scaffolds. A computer-aided design-based lock-and-key arrangement was used folding into with spatial arrangements. With encapsulating cells in paper, scaffold system able to deliver biological cues vivo. In this work, we have successfully applied origami-based engineering approach regeneration model.