Drosophila TRPA1 isoforms detect UV light via photochemical production of H 2 O 2

• DOI: 10.1073/pnas.1514862112
• Publication Date: 2015-10-07T02:08:29Z
• Authors: Ananya R. Guntur; Pengyu Gu; Kendra Takle; Jingyi Chen; Yang Xiang; Chung-Hui Yang
• Keywords: Toolbox

Significance Discovering new light-sensing mechanisms and cell types are of considerable interest to researchers across disciplines. Understanding how cells sense light is one the most fundamental problems in biology. In addition, optogenetics has become a critical research tool discovery may expand existing toolbox. this work, we described our dTRPA1-dependent photochemical pathway that sufficient confer UV sensitivity light-insensitive cells. We also discovered group neuroendocrine express these isoforms endogenously can UV. These findings demonstrate type strong potential exploiting dTRPA1 channel as an optogenetic tool.