Tracking solvents in the skin through atomically resolved measurements of molecular mobility in intact stratum corneum

• DOI: 10.1073/pnas.1608739114
• Publication Date: 2016-12-28T01:50:24Z
• Authors: Quoc Dat Pham; Daniel Topgaard; Emma Sparr
• Keywords: Corneocyte

Significance Our skin is regularly exposed to solvents in cosmetics, washing and sanitary agents, drug formulations. The uptake of into the may change essential properties skin, for example, its protective barrier function, as well flexibility softness. Herein different relevant formulations products were added samples intact stratum corneum (SC), which outer layer skin. solvent molecules can be tracked inside SC, showing reduced mobility. Furthermore, induce fluidity SC components. These changes depend on identity concentration hydration conditions. Changes components related macroscopic including function.