Regulation of embryonic neurogenesis by germinal zone vasculature

• DOI: 10.1073/pnas.1613113113
• Publication Date: 2016-11-08T03:55:04Z
• Authors: Mathew Tata; Ivan Wall; Andy Joyce; Joaquim M. Vieira; Nicoletta Kessaris; Christiana Ruhrberg
• Keywords: Forebrain; Progenitor; Hindbrain; Hypoxia

Significance Neural progenitor cells (NPCs) proliferate to generate precursors for new neurons. To sustain this process, NPCs balance self-renewal with the generation of progeny committed neuronal differentiation. In adult mammalian brain, blood vessels and vessel-derived factors help regulate by modulating NPC proliferation quiescence, independently vascular roles in providing oxygen nutrients. contrast, it has been proposed that vasculature regulates behavior developing forebrain alleviating tissue hypoxia. We show here germinal zone embryonic hindbrain neuron production, oxygenation. Information on how neurogenesis may aid design therapies brain regeneration injury disease.