Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit

• DOI: 10.1073/pnas.1702914114
• Publication Date: 2017-09-19T01:00:20Z
• Authors: Tobias Otto; Sheyla V. Candido; Mary S. Pilarz; Ewa Sicinska; Roderick T. Bronson; Michaela Bowden; Iga A. Lachowicz; Kristin Mulry; Anne Fassl; Richard C. Han; Emmanuelle S. Jec...; Piotr Sicinski
• Keywords: Derepression; Cell fate determination

Significance The interplay between microRNAs and the cell-cycle machinery in vivo remains poorly understood. Here we report that microRNA family miR-34/449 plays an essential rate-limiting role repressing proteins enforcing exit during epithelial cell differentiation. We demonstrate genetic ablation of entire leads to derepression cycle-promoting differentiating cells, thereby preventing their timely exit. This, turn, impairs ciliation profound developmental defects. Hence, this study describes a function linking proliferation