NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor

• DOI: 10.1073/pnas.1706917114
• Publication Date: 2017-09-19T01:00:20Z
• Authors: Arturo Mendoza; Inna Astapova; Hiroaki Shimizu; Molly R. Gallop; Lujain Al-Sowaimel; S. M. Dileas MacG...; Tim Bergmann; Anders H. Berg; Danielle E. Tenen; Christopher Jacobs; Anna Lyubetskaya; Linus Tsai; Anthony N. Hollen...
• Keywords: Corepressor; Thyroid hormone receptor

Significance Thyroid hormone receptors (TRs) mediate the genomic actions of thyroid hormones. In absence T3 (3,3′,5-triiodothyronine), TR recruits a multiprotein repressor complex that decreases histone acetylation in vicinity target genes. Nuclear receptor corepressor 1 (NCoR1) is hypothesized to be main interacts with TR. Here we report deletion NCoR1 does not prevent all gene repression and deacetylation across variety mouse models, whereas only lack was able overturn effects hypothyroidism. Thus, conclude sufficient unliganded TR; furthermore, our data suggest alternative mechanisms may involved action TRs.