SIRPα+dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen

• DOI: 10.1073/pnas.1711345114
• Publication Date: 2017-11-06T20:21:24Z
• Authors: Yasuyuki Saito; Datu Respatika; Satomi Komori; Ken Washio; Taichi Nishimura; Takenori Kotani; Yoji Murata; Hideki Okazawa; Hiroshi Ohnishi; Yoriaki Kaneko; Katsuyuki Yui; Koji Yasutomo; Chikako Nishigori; Yoshihisa Nojima; Takashi Matozaki
• Keywords: Homeostasis; Reticular cell; CD47; Follicular dendritic cells

Significance Homeostasis of Pdpn + fibroblastic reticular cells (FRCs) is thought to be regulated by hematopoietic cells. However, the cellular and molecular mechanisms such homeostasis have been poorly understood, especially under steady-state condition in adults. We show that dendritic cells, particularly CD4 conventional (cDCs), are crucial for FRCs adult spleen condition. The production TNF receptor ligands cDCs regulates FRCs, with SIRPα CD47 likely being indispensable TNFR cDCs. CD47–SIRPα interaction on may thus control which turn maintain T white pulp spleen.