MPSR1 is a cytoplasmic PQC E3 ligase for eliminating emergent misfolded proteins in Arabidopsis thaliana

• DOI: 10.1073/pnas.1713574114
• Publication Date: 2017-10-30T18:57:17Z
• Authors: Jong Hum Kim; Seok Keun Cho; Tae Rin Oh; Moon Young Ryu; Seong Wook Yang; Woo Taek Kim
• Keywords: Ubiquitin-Protein Ligases; Aggresome

Significance The essential roles of cytoplasmic E3 ligases in the protein quality control (PQC) pathways have been increasingly highlighted yeast and animal studies. However, plants, only CHIP ligase has characterized, while knowledge PQC remains rudimentary. Misfolded Protein Sensing RING 1 (MPSR1), a self-regulatory sensor system that functions occurrence misfolded proteins, is an identified plants directly recognizes emergent proteins independently chaperones. In addition, MPSR1 sustains integrity activity 26S proteasome under proteotoxic stress. Given well conserved eukaryotes, this study sheds light on pathway present particularly beyond.