Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster

• DOI: 10.1073/pnas.1719033115
• Publication Date: 2018-06-18T20:43:50Z
• Authors: Jun Young Sonn; Jongbin Lee; Min Kyung Sung; Hwajung Ri; Jung Kyoon Choi; Chunghun Lim; Joonho Choe
• Keywords: Sleep; Metabolic pathway

Significance Foraging and sleep are two conflicting behaviors in starved animals; however, it remains elusive how metabolic status governs drive. In this study, we show that a biosynthetic pathway for the amino acid serine is transcriptionally up-regulated by starvation adult fly brains. The behavioral response to genetic manipulation of key enzymes involved metabolism supports sleep-suppressing effect starvation. society where daily diet becoming increasingly important quality individuals, our study defines an underlies adaptive upon dietary stress.