Structural mechanism of Myb–MuvB assembly

• DOI: 10.1073/pnas.1808136115
• Publication Date: 2018-09-17T19:15:42Z
• Authors: Keelan Z. Guiley; Audra N. Iness; Siddharth Saini; Sarvind Tripathi; Joseph S. Lipsick; Larisa Litovchick; Seth M. Rubin
• Keywords: MYB

The MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, cooperates with B-Myb to activate genes required for the G2 and M phases of cell cycle. We have identified domain in that is essential assembly Myb–MuvB (MMB) complex. determined a crystal structure reveals how this binds through adaptor protein LIN52 scaffold LIN9. biochemical analysis provide an understanding oncogenic recruited regulate cell-cycle progression, MMB interface presents potential therapeutic target inhibit cancer proliferation.