Changes in membrane properties of rat deep cerebellar nuclear projection neurons during acquisition of eyeblink conditioning

• DOI: 10.1073/pnas.1808539115
• Publication Date: 2018-08-28T17:25:22Z
• Authors: Desheng Wang; Carrie A. Smith-Bell; Lauren B. Burhans; Deidre E. O’Dell; Roger W. Bell; Bernard G. Schreurs
• Keywords: Eyeblink conditioning; Hyperpolarization; Stimulus (psychology); Deep cerebellar nuclei

Significance Although large ensembles of neurons have been found to change as a function learning and memory, localizing those changes the individual directly involved in specific task has challenging. Using whole-cell recording deep cerebellar nuclear (DCN) transsynaptic viral tracer, we motor induced significant membrane properties rat DCN projection including reduced after-hyperpolarization amplitude shortened latency for both evoked action potentials rebound spikes. These learning-specific excitability not previously reported any species or task.