Gray Matter Age Prediction as a Biomarker for Risk of Dementia

• DOI: 10.1073/pnas.1902376116
• Publication Date: 2019-10-01T21:04:34Z
• Authors: Johnny Wang; Maria J. Knol; Aleksei Tiulpin; Florian Dubost; Marleen de Bruijne; Meike W. Vernooij; Hieab H. H. Adams; M. Arfan Ikram; Wiro J. Niessen; Gennady V. Roshch...
• Keywords: Brain Aging

Significance The difference between brain age estimated from MRI and chronological is thought to serve as an important biomarker reflecting pathological processes in the brain. Several recent studies showed relation accelerated aging various disorders. However, until now, utility of such for preclinical screening using longitudinal was absent. To fill this gap, we first built a deep learning model population-based study including 5,496 participants. And then, follow-up information, observed that significantly associated with risk dementia. Therefore, our shows MRI-brain predicted potentially early dementia screening.