Recognition with metallo cavitands

• DOI: 10.1073/pnas.1909154116
• Publication Date: 2019-08-20T00:25:03Z
• Authors: Faiz-Ur Rahman; Yong-sheng Li; Ioannis D. Petsal...; Giannoula Theodor...; Julius Rebek; Yang Yu
• Keywords: Cavitand; Quinoxaline; Molecular Recognition; Host–guest chemistry

Significance Cavitands are nanoscale container molecules widely used in studies of molecular recognition and reactivity. They act as hosts that temporarily confine small molecule guests much their action reaction chambers is due to movable walls allowing the uptake release guests. Water-soluble organic-soluble cavitands featuring quinoxaline were prepared complexes with alkanes, amphiphilic characterized by 1 H NMR spectroscopy computational methods. The quinoxalines bound Pd(II) near rim distorted shape space, stabilized receptive forms, enhanced guest binding. Further development application vessels depends on closely positioned charges potentially interactive sites cavity its contents.