Future epidemiological and economic impacts of universal influenza vaccines

• DOI: 10.1073/pnas.1909613116
• Publication Date: 2019-09-24T00:35:48Z
• Authors: Pratha Sah; Jorge A. Alfaro-M...; Meagan C. Fitzpat...; Kathleen M. Neuzil; Lauren A. Meyers; Burton H. Singer; Alison P. Galvani
• Keywords: Vaccine efficacy; Investment; Seasonal influenza

Significance Diminished efficacy of influenza vaccines has fueled research and funding for a broadly protective vaccine. NIAID recently proposed at least 75% against symptomatic as key criterion universal Our analyses demonstrate that with would be highly impactful in reducing the epidemiological impacts seasonal both national state levels. Reduced incidence hospitalizations due to vaccine distribution save $3.5 billion influenza-related direct medical costs per year. This economic benefit surpasses current $330 million combined toward development results highlight benefits rollout justify significant investment required development.