Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity

• DOI: 10.1073/pnas.1912772117
• Publication Date: 2020-09-29T00:26:41Z
• Authors: Wouter Laurentius...; Claudia Nanette S...; Ruben Johannes de...; Prashanthi Ramesh; Tânia Martins Garcia; Bartolomeus Joann...; Jacqueline Ludovi...; Marco Lezzerini; Alyson Winfried M...; Jan Koster; Jan Paul Medema; Gijs Robert van d...; Vanesa Muncan; Jarom Heijmans
• Keywords: Translational efficiency

Significance Deregulated global mRNA translation is a feature of various cancers and considered important in oncogenic transformation. In colorectal cancer (CRC), the role most common driver mutations APC , KRAS SMAD4 TP53 on translational capacity are incompletely understood. Here, using mouse human intestinal organoids, we found that each mutation governs epithelial cell. Global linked to known hallmarks, including cell proliferation growth upon accumulation these mutations, posing apparatus as potential therapeutic target CRC.