A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction

• DOI: 10.1073/pnas.2011614117
• Publication Date: 2020-11-24T02:31:52Z
• Authors: Lisa K. Mullany; Aarti D. Rohira; John P. Leach; Jong H. Kim; Tanner O. Monroe; Andrea R. Ortiz; Brittany Stork; M. Waleed Gaber; Poonam Sarkar; Andrew G. Sikora; Todd K. Rosengart; Brian York; Yongcheng Song; Clifford C. Dacso; David M. Lonard; James F. Martin; Bert W. O’Malley
• Keywords: Ventricular remodeling; Tissue Repair

Significance We are at an exciting era of identification the cell and molecular processes necessary for tissue remodeling repair. Unlike current systemic therapeutics, our studies reveal pharmacologic stimulation SRCs modulates macrophage fibrotic reparative responses to promote more effective repair lasting beneficial after myocardial infarction.