Pathological α-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of α-syn in vivo

• DOI: 10.1073/pnas.2108489118
• Publication Date: 2021-12-10T20:40:54Z
• Authors: Kristina Fredriksen; Stefanos Aivazidis; Karan Sharma; Kevin J. Burbidge; Caleb Pitcairn; Friederike Zunke; Eilrayna Gelyana; Joseph R. Mazzulli
• Keywords: Glycosphingolipid; Synucleinopathies; Neuropathology

mutations that encode lysosomal β-glucocerebrosidase (GCase) cause the storage disorder Gaucher disease (GD) and are strong risk factors for synucleinopathies, including Parkinson's Lewy body dementia. Only a subset of subjects with