Discovering disease-causing pathogens in resource-scarce Southeast Asia using a global metagenomic pathogen monitoring system

• DOI: 10.1073/pnas.2115285119
• Publication Date: 2022-03-02T16:58:25Z
• Authors: Jennifer A. Bohl; Sreyngim Lay; Sophana Chea; Vida Ahyong; Daniel M. Parker; Shannon Gallagher; Jonathan Fintzi; Somnang Man; Aiyana Ponce; Sokunthea Sreng; Dara Kong; Fabiano Oliveira; Katrina Kalantar; Michelle Tan; Liz Fahsbender; Jonathan Sheu; Norma Neff; Angela M. Detweiler; Christina Yek; Sokna Ly; Rathanak Sath; Chea Huch; Hok Kry; Rithea Leang; Rekol Huy; Chanthap Lon; Cristina M. Tato; Joseph L. DeRisi; Jessica E. Manning
• Keywords: Identification

SignificanceMetagenomic pathogen sequencing offers an unbiased approach to characterizing febrile illness. In resource-scarce settings with high biodiversity, it is critical identify disease-causing pathogens in order understand burden and prioritize efforts for control. Here, metagenomic next-generation (mNGS) characterization of the landscape Cambodia revealed diverse vector-borne zoonotic irrespective age gender as risk factors. Identification key led changes national program surveillance. This study a "real world" example use mNGS surveillance individuals, executed in-country, outbreaks vector-borne, zoonotic, other emerging setting.